This research project is aiming to evaluate the G6PD status of a group of up to 700 healthy volunteers and identify individuals with G6PD deficiency.
Results for each participant will be recorded in a database which may be used in the future by the Centre for Clinical Studies to recruit participants with a G6PD deficiency for future clinical trials. Participants who consent to this study may be contacted and invited to participate in further studies.
Genes are made of DNA – the chemical structure carrying your genetic information that determines many human characteristics such as the colour of your eyes or hair. Researchers study genes in order to understand why some people have a certain condition such as Favism (a reaction to eating broadbeans which is caused by a severe deficiency in G6PD enzyme) and why some people do not. Glucose-6-phospate dehydrogenase (G6PD) is an enzyme found in all cells that is vital for the defence of the cell against break down by hydrogen peroxide. G6PD deficiency is a common genetic variant that is more frequent in males than females and also more common in people from tropical areas. Understanding a person’s G6PD status also may be able to explain why some people respond to a treatment, while others do not, or why some people experience a side effect and others do not.
G6PD is estimated to affect 400 million people worldwide and is found in higher prevalence in populations exposed to particular medications. Most people would not know they have the G6PD deficiency as there are no symptoms. It is only when you are exposed to certain foods, infections, or drugs that you may develop anaemia (deficiency of red cells or of haemoglobin in the blood, resulting in pallor and weariness). Multiple drugs have been demonstrated to induce anemia in individuals with G6PD deficiency. These include Naphthalene, Nitrofurantoin and Primaquine. Depending on the G6PD variant the level of haemolysis may be mild, moderate or severe.
To find out more, you can call us on 1800 243 733 or click below to register your interest in this study.